Housing campaigners claim Bottle Brook could be a severe flooding hazard if a series of large housing applications are passed near Ripley.
The small channel of water already carries surface drainage water from hundreds of homes in the Ripley and Marehay area to the River Derwent.
But campaigner Jonathan Hunt, of the Amber Valley SOS group, claims it will be at bursting point if six major building developments, comprising more than 600 homes, are completed within a two square mile area of Waingroves.
He said: “The surface water from all of these development sites will ultimately be deposited into Bottle Brook.
“The alarming prospect of thousands of additional gallons of run-off water entering the Bottle Brook watercourse just to the north of Marehay is a great concern to many residents who live near to the Bottle Brook Floodplain.
“Derby Road, Denby, Rawson Green, Kilburn and Lower Kilburn are all adjacent to the Bottle Brook Floodplain and they have all experienced flooding problems over the years. These areas are still encountering problems.”
Proposed planning to use Bottle Brook as a drainage facility is included in a plan for 360 new homes at Whiteley Roa din Ripley, at the former Hansons brickworks site.
The proposed new commercial village at Denby Pottery, which includes a possible 80-bed hotel and a new distribution warehouse, would also utilise the brook to convey drainage water to the Derwent.
Developments at Greenhillocks for 171 homes and at the former Apollo Engineering site in Marehay for 22 homes are already underway alongside the watercourse.
Mr Hunt is demanding Amber Valley Borough Council takes potential flooding issues into consideration before consenting to the building sites yet to achieve planning permission.
He said: “We cannot consider all these plans individually . Bottle Brook can’t handle any more.”
Mr Hunt has passed his concerns to Severn Trent Water and the Environment Agency, which has already expressed concerns over the development at Whiteley Road by Sheffield-based Hallam Land management.
The agency has already objected to the 360-home plan because of the burden it would place on the Severn Trent sewerage treatment works at Marehay. In a statement the agency said the development would pose an “unacceptable risk of pollution,” stating also that the Hallam Land Management plan did not have a sufficient Flood Risk Assessment. A decision is expected on the plan by July 12.