The Yorkshire Bank on Oxford Street, in Ripley, is set for closure by the end of December.
It is one of a dozen branches earmarked for closure in Derbyshire as part of plan by Yorkshire and Clydesdale banks to shut 28 branches in England and Scotland. The group, part of National Australia Bank (NAB), expects to save £5 million by the branch closures and said that frontline jobs would be safeguarded.
Unite national officer Rob Macgregor said: “The bank is cutting costs and eroding community banking which we believe leaves customers with less choice. Unite will oppose compulsory redundancies.”