Burglars took designer jewellery and iPads from a house in Kirkley Drive, Heanor, on Thursday, November 21.
The offence took place between 8am and 7pm that day while the homeowners were at work.
When they returned home they saw a hallway cupboard had been raided and a kitchen window forced open.
A Gucci necklace and a bracelet had been taken along with three watches of Armani and Pulsar make.
Police believe the raiders may have foist attempted to get into the house via a conservatory window.
If you have any information which could help police, call the force on 101.